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KMID : 0880220070450020146
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Journal of Microbiology
2007 Volume.45 No. 2 p.146 ~ p.152
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Identification and Characterization of the Vibrio vulnificus rtxA Essential for Cytotoxicity in vitro and Virulence in Mice
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Lee Jeong-Hyun
Kim Myung-Won
Kim Byoung-Sik
Kim Seung-Min
Lee Byung-Cheol
Kim Tae-Sung
Choi Sang-Ho
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Abstract
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A mutant exhibiting decreased cytotoxic activity toward INT-407 intestinal epithelial cells and carrying a mutation in the rtx gene cluster that consists of rtxCA and rtxBDE operons was screened from a library of V. vulnificus mutants. The functions of the rtxA gene, assessed by constructing an isogenic mutant and evaluating its phenotypic changes, demonstrated that RtxA is essential for the virulence of V. vulnificus in mice as well as in tissue cultures.
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KEYWORD
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Vibrio vulnificus, RtxA, cytotoxicity, virulence
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